This research investigated the determinants influencing support for the implementation of pre-exposure prophylaxis (PrEP) among adolescent girls and young women (AGYW) in two healthcare clinics in Soweto, South Africa. The study employed a tailored questionnaire administered to 40 nurse-initiated management of antiretroviral therapy (NIMART) professional nurses.

Limitations included convenience sampling, a small sample size and geographical constraints in Soweto, potentially limiting generalisability. Social desirability bias and reliance on self-reported data were other acknowledged limitations.

Despite these limitations, the research yielded insights into factors shaping support for PrEP implementation among healthcare professionals. These findings can inform HIV/Aids prevention programme management, offering practical strategies to enhance PrEP implementation. The study represented a significant stride in advancing HIV prevention efforts among AGYW, with implications for broader public health initiatives.